Global Certificate in Nanomaterials Nanoparticle Drug Delivery

• Introduction to Nanomaterials and Nanoparticle Drug Delivery: Basics of nanomaterials, properties, and applications in drug delivery systems. Understanding of nanoparticle fabrication and characterization techniques. • Pharmacokinetics and Pharmacodynamics of Nanoparticle Drug Delivery: Principles of pharmacokinetics and pharmacodynamics, factors affecting drug delivery, and the impact of nanoparticles on drug bioavailability, distribution, metabolism, and excretion. • Nanoparticle Design and Synthesis: Methods for designing and synthesizing various types of nanoparticles (liposomes, polymeric nanoparticles, dendrimers, carbon nanotubes, etc.) and selecting the appropriate nanoparticle for a specific drug delivery application. • Drug Loading and Release Mechanisms: Techniques for loading drugs into nanoparticles, control of drug release rates, and various release mechanisms (diffusion, swelling, erosion, and degradation). • Targeted Drug Delivery: Approaches to designing targeted drug delivery systems using nanoparticles, including active and passive targeting strategies, and their impact on improving drug efficacy and reducing side effects. • Nanoparticle-Mediated Gene Delivery: Principles of gene delivery, gene therapy, and the use of nanoparticles for gene delivery applications, including DNA, RNA, and siRNA delivery. • Nanoparticle Safety and Toxicity: Assessment of nanoparticle safety and toxicity, including in vitro and in vivo testing, and mitigation strategies to minimize toxicity and improve nanoparticle biocompatibility. • Regulatory and Ethical Considerations: Overview of regulatory and ethical considerations for nanoparticle drug delivery, including regulatory requirements, clinical trial design, and ethical considerations for human use.